[发明专利]一种诊断多发性骨髓瘤的分子影像探针

权利要求书

1.一种诊断多发性骨髓瘤的分子影像探针，其特征在于，所述探针包括肿瘤靶向基团、螯合剂和放射性核素，所述肿瘤靶向基团为一种CD38特异性单域抗体，所述螯合剂为大环配体或无环配体，所述大环配体包括1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)、1,4,7-三氮杂环壬烷-1,4,7-三乙酸(NOTA)、1,4,8,11-四氮杂环十四烷-1,4,8,11-四乙酸(TETA)和1,4,7-三氮杂环壬烷-1,4,7-三(亚甲基膦酸) (NOTP)中的一种，所述放射性核素为Ga-68，所述螯合剂为1,4,7-三氮杂环壬烷-1,4,7-三乙酸(NOTA)，所述单域抗体具有如下氨基酸序列之一：

Met His His His His His His Asp Val Gln Leu Gln Glu Ser Gly Gly Gly LeuVal Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Arg Thr Phe ArgAsn Tyr Pro Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val AlaGly Ile Thr Trp Val Gly Ala Ser Thr Leu Tyr Ala Asp Phe Ala Lys Gly Arg PheThr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu LysPro Glu Asp Thr Ala Val Tyr Ser Cys Ala Ala Gly Arg Gly Ile Val Ala Gly ArgIle Pro Ala Glu Tyr Ala Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser GlyGly Gly Gly Ser Gly Gly Gly Gly Ser Leu Leu Gln Ser，

或者Met His His His His His His Asp Val Gln Leu Gln Glu Ser Gly Gly GlyLeu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Arg Thr PheArg Asn Tyr Pro Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe ValAla Gly Ile Thr Trp Val Gly Ala Ser Thr Leu Tyr Ala Asp Phe Ala Lys Gly ArgPhe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser LeuLys Pro Glu Asp Thr Ala Val Tyr Ser Cys Ala Ala Gly Arg Gly Ile Val Ala GlyArg Ile Pro Ala Glu Tyr Ala Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser SerGly Gly Gly Gly Ser Cys Gly Ser Gly Ser Gly Ser Leu Leu Gln Ser。