[发明专利]胶质母细胞瘤危险分层模型及其在临床预后评估的应用

权利要求书

1.一种用于胶质母细胞瘤患者的预后风险评估系统，所述的预后风险评估系统包括数据输入模块、模型计算模块和结果输出模块，所述的模型计算模块通过风险分层模型计算获得胶质母细胞瘤患者的模型值，所述的风险分层模型为：

Y＝Coe*X

Coe＝(0.014927198，0.009302326，...，0.017309391)，X＝(v₁，v₂，...，v₁₁₁)^T，

所述的Coe＝(0.014927198，0.009302326，0.006020697，0.009157401，0.008749802，0.012970721，0.014429021，0.006045153，0.009023346，0.009275152，0.009737098，0.008170105，0.001622246，0.009220806，0.010443604，0.004156609，0.012499717，0.007488961，0.006822309，0.002885804，0.008027898，0.013948959，0.014111999，0.006864881，0.01252689，0.011177283，0.016294921，0.008895632，0.004353162，0.012590295，0.017726048，0.012372908，0.005900229，0.007700913，0.008767012，0.012798623，0.005853128，0.004294287，0.006162904，0.002009918，0.006125767，0.00682865，0.015017776，0.004951881，0.011720749，0.013794977，0.01066099，0.004364032，0.01508118，0.016285863，0.016756867，0.001413917，0.004810579，0.010117525，0.007691855，0.010026947，0.014483368，0.009266095，0.004050633，0.001293449，0.001814271，0.003696474，0.00912117，0.01406671，0.003540681，0.006263445，0.002057924，0.017852857，0.001876769，0.014084826，0.005609474，0.0030262，0.012472544，0.004660221，0.009329499，0.003301556，0.003058808，0.009565001，0.016910849，0.007900183，0.014573945，0.004452798，0.012019655，0.00621091，0.006219062，0.001239102，0.00920269，0.017427142，0.009637463，0.003555173，0.003643939，0.014972487，0.015380087，0.01463735，0.010651933，0.010760626，0.017870972，0.006777926，0.004264396，0.013939902，0.01175698，0.016077534，0.01293449，0.005075972，0.007195489，0.002834175，0.003175653，0.003180182，0.011711691，0.011032359，0.017309391)；所述的X中v₁，v₁，……v₁₁₁为与所述的风险系数相对应的甲基化位点(cg07464524，cg09912841，cg11426662，cg25560327，cg24550026，cg09692771，cg13681847，cg16483490，cg20623601，cg24046888，cg25124739，cg02970696，cg05726118，cg07556134，cg12508343，cg18011163，cg24105729，cg00202441，cg01483139，cg02647878，cg02968741，cg08660876，cg09760963，cg18016365，cg07862423，cg13593479，cg17621438，cg04488476，cg09013068，cg12798992，cg00376553，cg01900030，cg02204205，cg02316066，cg05231706，cg05898452，cg06586813，cg08300570，cg11139102，cg11274371，cg15774495，cg18071865，cg21517389，cg21808635，cg22281380，cg23104539，cg25819027，cg27006764，cg01981354，cg24820936，cg24828864，cg17028652，cg12041266，cg16036142，cg21558509，cg12836863，cg26740195，cg04352704，cg00645339，cg04025675，cg05896902，cg09093388，cg10088041，cg19114050，cg24328539，cg25908973，cg26796135，cg00291054，cg01769813，cg06330323，cg06788514，cg06846976，cg07549381，cg07644807，cg08779982，cg08936056，cg26819590，cg06270615，cg06788790，cg07780782，cg09967973，cg10792831，cg17833746，cg18711081，cg19636308，cg25330422，cg26111030，cg05724997，cg14623989，cg14889643，cg17602451，cg21793948，cg23707289，cg26277730，cg06346838，cg08165462，cg12400781，cg13368085，cg13422347，cg14559388，cg24156854，cg00876694，cg01118078，cg02872693，cg16626405，cg16810054，cg17204562，cg21859623，cg26204638，cg19810954，cg26237628)的甲基化率，阈值为0.4385954。