[发明专利]美洲大蠊断肢再生相关Hedgehog信号通路基因及其dsRNA的应用有效
申请号: | 201810883915.X | 申请日: | 2018-08-06 |
公开(公告)号: | CN109207601B | 公开(公告)日: | 2019-08-27 |
发明(设计)人: | 李胜;任充华 | 申请(专利权)人: | 华南师范大学 |
主分类号: | C12Q1/6888 | 分类号: | C12Q1/6888;A01N57/16;A01P7/04 |
代理公司: | 广州嘉权专利商标事务所有限公司 44205 | 代理人: | 胡辉 |
地址: | 510631 广东省广州市*** | 国省代码: | 广东;44 |
权利要求书: | 查看更多 | 说明书: | 查看更多 |
摘要: | |||
搜索关键词: | 美洲大蠊 基因 再生 再生相关基因 害虫防治 靶点 害虫 应用 防治 | ||
1.抑制Hh、Ptc、Smo或/和Ci表达的试剂在制备阻断美洲大蠊断肢再生的试剂中的应用;
所述抑制Hh、Ptc、Smo或/和Ci表达的试剂为抑制Hh、Ptc、Smo或/和Ci RNA转录水平的试剂;
所述抑制Hh、Ptc、Smo或/和Ci RNA转录水平的试剂选自沉默Hh、Ptc、Smo或/和Ci表达的siRNA、沉默Hh、Ptc、Smo或/和Ci表达的shRNA和沉默Hh、Ptc、Smo或/和Ci表达的dsRNA的至少一种;
所述沉默Hh、Ptc、Smo或/和Ci表达的dsRNA选自以下序列:
靶向沉默Hh基因的dsRNA序列:
AACACCCUUCCAGCAAGCGGUCUCACCGAGGGGCGCGUGACCCGCAAAGACCCUCGCUUCAGGGAUCUGGUGCCCAACUACAACGCAGACAUCGUGUUCAAGGACGAGGAAGGCACGGGCGCCGACCGCCUCAUGACGCAGAGGUGCAAGGAGAAGCUGAACACGCUGGCCAUCUCGGUGAUGAACCAGUGGCCCGGCGUGAAGCUGCGGGUGACGGAGGGCUGGGACGAGGAGGGGCACCACGCCGUGGACUCGCUGCACUACGAGGGCCGAGCCGUCGACGUCACCACCUCCGACAGGGAUCGAGCCAAGUACGGCAUGCUGGCGCGCCUCGCCGUGGAGGCGGGCUUCGACUGGG(SEQ ID NO.17);
靶向沉默Ptc基因的dsRNA序列:
UUCGACGAGCACUAUAUAGACCAAAUAUUCCUAAACAUUAUCCCUUGUGCCAUCAUUACUCCAUUAGACUGUUUUUGGGAAGCUUCGAAGCUUCUGGGACCAGAUUAUCCUGUUCAAAUACCAGGCGUGGGCUCCAAGGUGCGCUGGACGAACCUUAACCCACAACAACUAAUCCAACAAAUGAAGACUGUCGAAUUGGUAUUCCCUUUCGAGACUCUCGAAGACUACAUGAAAAGGGCGGGGAUAAGCACGGGCUACCAAGAGAAGCCGUGUCUCGACCCCUCCGACCCCGAAUGCCCGACCACCGCCCCCAACAAGUUAUCCGGACAGAUACCUGACAUCGGGGCAGAGCUGACAGGAGGCUGCUACGGAUAUGCAGCCAAAUAUAUGCACUGGCCUGAGGACCUGGUGGUGGGCGGAGCCACACGAAAUAAGACUGGACACAUACAAAGGGCGCGUGCAUUGCAGACUGUGGUGCAACUAAUGGGAGAGAGAGAGAUGUAUGAAUUCUGGUCUAAAACGUACAAAGUCCAUCACUUGGAUUGGACACAAGAAAAAGCUGCUUUAAUUCUCGAGACAUGGCAGAGGC(SEQ ID NO.18);
靶向沉默Smo基因的dsRNA序列:
ACUUGUAAUUUUCUAUAUCAAUUGCUGUUUUUUGGUGUCAUGUAUUGGAUGGUUGGCACAGUUUAUUCCUGGUGCACGUGAAGGCAUUAUAUGCCGGAAAGAUGGUACUUUAAGGAUGUCAGAACCUAAUACUGGAGAGAAUUUGUCAUGUGUGAUAAUAUUUGUAUUGGUGUAUUACUUCAUCAUGGCUGCCUUUGUGUGGUUUGUAAUUCUCACGUACACAUGGCACAUCAGUUUUCAAGCUCUAGGUAAAAUUCAAGAGCGAAUUGAUAAGAAAAGUGCUUAUUUUCACAUGGUGGCUUGGUCAUUGCCUCUAGUUCUUACUAUUACAACUAUGGCACUAGGGGAAAUAGAUGGCGACAGUGUUGCUGGUAUCUGUUUUGUGGGAUAUGUUAAUCAUGCUGCACGAGCAGGAUUCUUGCUCGUCCCCAUUACAACAGUACUUUUUGUUGGAGGAUACUUUCUCACUAGGGGUCUUAUAACACUGGUGAGACUAAAAAUUAACAGUCAAGAAAUUAUCUCAGAAAGAGCAAGUGCCAAGAUAAGAGAAACCAUUGUGCGCAUGGGUCUCUUUUCACUGUUUACAUUUGUCUUUGUGUU(SEQID NO.19);
靶向沉默Ci基因的dsRNA序列:
GAUCUCGUCAAGCACAUCAACAAUGACCACAUUCAUGCCAACAAGAAGUCGUUUGUGUGCCGCUGGGAAGACUGUUCAAGGGACGAGAAGCCCUUCAAAGCGCAGUAUAUGCUGGUGGUGCACAUGCGACGACACACAGGGGAGAAGCCCCACAAAUGUACAUUUGAAGGGUGCUACAAAGCCUAUUCGAGGCUGGAGAACCUGAAGACGCACCUCAGAUCUCAUACAGGAGAAAAACCCUACAUGUGUGAGUAUCCUGGAUGCAGCAAAGCCUUCAGCAAUGCGUCCGACCGUGCCAAACACCAGAACCGCACGCACUCCAACGAGAAACCGUACGUGUGUAAGGCCCCGGGCUGCACCAAGAGGUACACAGACCCCAGUUCGCUGCGGAAGCACGUGAAGACAGUGCACGGUGCCGAGUUCUAUGCCAACAAGAAGCACAAGGGAGCUGGCGACGGCGCCGAGGAUGGCUCUGGAGGGGCGGGAGGCCUACUGGACAGCAGCCCGCACAGCGAGGAGAUGAUGAGCGGCAAGACGGCC(SEQ ID NO.20)。
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