[发明专利]异吲哚酮的三氟甲基羟基化衍生物的制备方法

权利要求书

1.一种异吲哚酮的三氟甲基羟基化衍生物的制备方法，其特征在于，包括以下步骤:

将式(1)的取代N-苯基-3-苯亚甲基异吲哚-1-酮衍生物和三氟甲基亚磺酸钠在铜盐的催化作用以及氧化剂的氧化作用下，在溶剂中于10～80℃下反应，得到式(2)的异吲哚酮的三氟甲基羟基化衍生物，以上反应的路线如下：

其中，R¹、R²、R³、R⁴、R⁵、R⁶、R⁷、R⁸、R⁹、R¹⁰、R¹¹和R¹²独立地选自氢、烷基、烷氧基或卤素。

2.根据权利要求1所述的异吲哚酮的三氟甲基羟基化衍生物的制备方法，其特征在于:

R¹、R²、R³、R⁴、R⁵、R⁶、R⁷、R⁸、R⁹、R¹¹、R¹²为氢，R¹⁰为氢、烷基、烷氧基或卤素；

或R¹、R²、R³、R⁴、R⁵、R⁶、R⁷、R⁸、R¹⁰、R¹¹、R¹²为氢，R⁹为氢、烷基或卤素；

或R¹、R²、R³、R⁴、R⁵、R⁶、R⁷、R⁹、R¹⁰、R¹¹、R¹²为氢，R⁸为氢、烷基或卤素；

或R¹、R²、R⁴、R⁶、R⁷、R⁸、R⁹、R¹⁰、R¹¹、R¹²为氢，R⁵为氢、烷基或卤素；

或R¹、R²、R³、R⁵、R⁷、R⁸、R⁹、R¹⁰、R¹¹、R¹²为氢，R⁴为氢、烷基、烷氧基或卤素；

或R¹、R²、R⁴、R⁵、R⁷、R⁸、R⁹、R¹⁰、R¹¹、R¹²为氢，R³为氢、烷基或卤素；

或R³、R⁴、R⁵、R⁶、R⁷、R⁸、R⁹、R¹⁰、R¹¹、R¹²为氢，R¹和R²分别为氢或烷基。

3.根据权利要求1或2所述的异吲哚酮的三氟甲基羟基化衍生物的制备方法，其特征在于:所述烷基为甲基、乙基或丙基。

4.根据权利要求1或2所述的异吲哚酮的三氟甲基羟基化衍生物的制备方法，其特征在于:所述烷氧基为甲氧基或乙氧基。