[发明专利]适用于预测对醋酸格拉替雷的临床反应的单核苷酸多态性

摘要

提供了一种使用包含醋酸格拉替雷和医药学上可接受的载剂的医药组合物治疗罹患多发性硬化症或与多发性硬化症一致的单一临床发作的人类个体的方法，所述方法包含以下步骤：判定所述个体在一或多种单核苷酸多态性(SNP)的基因型，基于所判定的SNP基因型鉴别所述个体为醋酸格拉替雷的预测反应者或非反应者，以及仅当所述个体被鉴别为醋酸格拉替雷的预测反应者时才向所述个体投与所述包含醋酸格拉替雷和医药学上可接受的载剂的医药组合物。

主权项

一种使用包含醋酸格拉替雷(glatiramer acetate)和医药学上可接受的载剂的医药组合物治疗罹患多发性硬化症或与多发性硬化症一致的单一临床发作的人类个体的方法，所述方法包含以下步骤：i.判定所述个体在一或多种选自由以下组成的群组的单核苷酸多态性(SNP)的基因型：rs1007328、rs10083547、rs10136012、rs10214633、rs10277267、rs1040194、rs1041897、rs10853605、rs10931091、rs10935015、rs10935016、rs10935019、rs10950359、rs10950371、rs10988087、rs11009827、rs11009835、rs11081859、rs11599624、rs11617134、rs11618546、rs11694344、rs11709339、rs11719825、rs11761457、rs11907046、rs12055694、rs12256889、rs1229542、rs1229553、rs1229555、rs1229558、rs1229562、rs1229563、rs1229564、rs1229568、rs12340584、rs1234567、rs1234947、rs1237625、rs12488259、rs12494606、rs12496278、rs12524041、rs12529764、rs12532459、rs12540494、rs12593600、rs12633010、rs12637073、rs12639443、rs1264423、rs1282540、rs1282546、rs12968586、rs1299325、rs13021482、rs13042992、rs1320648、rs13238613、rs13245980、rs1415557、rs1538123、rs1573706、rs1591661、rs1611185、rs1683691、rs16999008、rs17007730、rs17087180、rs17104665、rs17104742、rs17134651、rs17575455、rs17588454、rs17666347、rs17771939、rs17807327、rs17807445、rs1886308、rs1892974、rs1941973、rs2033471、rs2088713、rs214526、rs2155262、rs2177073、rs2187495、rs2277431、rs2305623、rs2374730、rs2461319、rs2487889、rs2487896、rs2508806、rs2511064、rs2521643、rs2521644、rs2530121、rs2530123、rs2685484、rs2722396、rs2722398、rs28861531、rs2895215、rs2937395、rs3135391、rs35831078、rs3742228、rs401618、rs4148871、rs4255033、rs4281882、rs4289164、rs4306478、rs4343256、rs4344916、rs4369324、rs4435429、rs4445746、rs4466940、rs4468448、rs4483642、rs4565951、rs4578835、rs4634524、rs4799760、rs4809955、rs4811492、rs496486、rs552994、rs6015147、rs6025923、rs6025927、rs6091820、rs6097782、rs6097790、rs6097793、rs6097797、rs6097801、rs6123749、rs6543934、rs6558102、rs656975、rs657302、rs6584894、rs660075、rs6713772、rs6909321、rs6971202、rs702355、rs7080507、rs7086707、rs7093143、rs7178587、rs7180867、rs7232734、rs7238006、rs7244801、rs7317000、rs751370、rs752979、rs7619350、rs7633210、rs7714122、rs7789703、rs7803164、rs7806265、rs7916897、rs7955917、rs7963693、rs8099595、rs8118441、rs844602、rs844608、rs844610、rs844612、rs844626、rs860722、rs873216、rs884266、rs894857、rs913882、rs9315048、rs9332420、rs933863、rs933864、rs9378319、rs9378684、rs9392358、rs9405541、rs9405546、rs947603、rs948029、rs948032、rs949298、rs9508834、rs9944913、rs9952995以及rs998051，ii.如果所述基因型为下述，那么鉴别所述个体为醋酸格拉替雷的预测反应者，AA，位于rs10214633、rs10277267、rs10935015、rs10935019、rs10988087、rs11081859、rs11694344、rs12256889、rs12340584、rs12494606、rs1415557、rs17007730、rs17087180、rs17104665、rs17104742、rs17588454、rs17807327、rs1892974、rs2088713、rs214526、rs2374730、rs4255033、rs4306478、rs4343256、rs4344916、rs4435429、rs4578835、rs4809955、rs496486、rs6015147、rs6097790、rs6584894、rs6713772、rs6909321、rs702355、rs7086707、rs7180867、rs7317000、rs844608、rs844610、rs933863、rs9392358、rs948029或rs9508834，AT，位于rs12524041或rs7806265，AG，位于rs10277267、rs10950359、rs11599624、rs13245980、rs1415557、rs2521643、rs4255033、rs6584894、rs6909321、rs702355或rs844626，AC，位于rs12256889、rs1229542、rs214526、rs6097793、rs7086707、rs7180867、rs844608或rs844610，TT，位于rs1007328、rs10931091、rs11617134、rs11709339、rs11719825、rs11761457、rs1229553、rs1234567、rs1234947、rs12532459、rs12593600、rs1264423、rs13042992、rs1320648、rs1538123、rs1591661、rs17134651、rs17666347、rs17771939、rs2461319、rs2508806、rs2722396、rs2722398、rs2895215、rs401618、rs4369324、rs4483642、rs4565951、rs4811492、rs552994、rs6025923、rs6025927、rs6097797、rs657302、rs7232734、rs751370、rs7633210、rs7714122、rs7803164、rs7806265、rs7916897、rs8118441、rs844612、rs9378319或rs9952995，GT，位于rs12532459、rs2722398、rs4369324或rs7093143，CT，位于rs10950371、rs11761457、rs1229562、rs12529764、rs13021482、rs13238613、rs1538123、rs1591661、rs1611185、rs17807445、rs1941973、rs2461319、rs2685484、rs2895215、rs4634524、rs4799760、rs6097797、rs7080507、rs7238006、rs7789703、rs7803164、rs844612或rs947603，GG，位于rs10083547、rs10136012、rs10950359、rs11599624、rs12055694、rs1229558、rs1237625、rs12496278、rs12540494、rs12633010、rs12637073、rs1282540、rs1282546、rs12968586、rs1299325、rs13245980、rs16999008、rs17104665、rs17104742、rs2033471、rs2155262、rs2487889、rs2487896、rs2511064、rs2521643、rs2530121、rs2530123、rs28861531、rs3135391、rs4148871、rs4289164、rs4445746、rs6097801、rs6543934、rs6558102、rs656975、rs6971202、rs7093143、rs7244801、rs752979、rs7619350、rs7955917、rs844626、rs873216、rs894857、rs9315048、rs9332420、rs933864、rs948032、rs949298或rs998051，CG，位于rs11618546或rs860722，或CC，位于rs1041897、rs10853605、rs10935016、rs10950371、rs11009827、rs11009835、rs11618546、rs11907046、rs1229542、rs1229555、rs1229562、rs1229563、rs1229564、rs1229568、rs12488259、rs12639443、rs13021482、rs13238613、rs1573706、rs1683691、rs17575455、rs17807445、rs2177073、rs2187495、rs2277431、rs2521644、rs2685484、rs2937395、rs4281882、rs4466940、rs4468448、rs4634524、rs4799760、rs6091820、rs6097782、rs6097793、rs6123749、rs660075、rs7080507、rs7789703、rs7963693、rs8099595、rs844602、rs860722、rs884266、rs913882、rs9378684、rs9405541、rs9405546、rs947603或rs9944913；以及iii.仅当所述个体被鉴别为醋酸格拉替雷的预测反应者时才向所述个体投与所述包含醋酸格拉替雷和医药学上可接受的载剂的医药组合物。