[发明专利]一种化合物及其制备方法和应用

摘要

本发明涉及生物化学领域，公开了一种化合物。本发明所述化合物具有式I所示结构，本发明所述式I所示化合物以宿主自身保守细胞蛋白PCAFBRD为作用靶点，具有潜在解决HIV病毒高度变异所带来的抗药性问题，有较好的抑制HIV病毒的增殖的活性，且对人正常淋巴细胞的毒性较低，能够应用于抑制HIV病毒增殖的药物的制备中，

主权项

1.一种化合物，其特征在于，具有式I所示结构：其中，R₁、R₂、R₃、R₄独立选自于-H、-(CH₂)_0-4-CH₃、-(CH₂)_0-4-CH₂Cl、-(CH₂)_0-4-CH₂Br、-CF₃、-(CH₂)_0-4-OH、-(CH₂)_0-4-O-(CH₂)_0-4-CH₃、-(CH₂)_0-4-O-CH(O)-(CH₂)_0-4-CH₃、-(CH₂)_0-4-CH-(CH₃)₂、-(CH₂)_0-4-Ar、-C(O)-(CH₂)_0-4-CH₃、-C(O)-O-(CH₂)_0-4-CH₃、-C(O)-NH₂、-C(O)-OH、-C(O)-O(CH₂)_0-4-CH₃、-C(O)-O(CH₂)_0-4-Ar、-C(O)-NH-(CH₂)_0-4-CH₃、-C(O)-N-[(CH₂)_0-4-CH₃]₂、-OH、-SH、-O-(CH₂)_0-4-CH₃、-O-C(O)-(CH₂)_0-4-CH₃、-O-(CH₂)_0-4-CH-(CH₃)₂、-O-(CH₂)_0-4-Ar、-NH₂、-NH-(CH₂)_0-4-CH₃、-NH-(CH₂)_0-4-Ar、-NH-(CH₂)_0-4-NH₂、-N(CH₃)₂、-NH-C(O)-(CH₂)_0-4-CH₃、-NH-C(O)-(CH₂)_0-4-SAr、-NH-Ts、-F、-Cl、-Br、-I、-CN、-C＝C-(CH₂)_0-4-CH₃、-C＝C-Ar、-alkynyl-(CH₂)0-₄-CH₃、-alkynyl-A_r；R₅、R₆独立选自于-H、-(CH₂)_1-4-CH₃、-(CH₂)_1-4-Ar、-(CH₂)_1-4-NH₂、-(CH₂)_1-4-OH、-(CH₂)_1-4COOH、-(CH₂)_1-4-OC(O)CH₃、-(CH₂)_1-4-NHC(O)CH₃、-(CH₂)_1-4COOCH₃、-(CH₂)_1-4CONH₂、-(CH₂)_1-4-NOC₄H₈。