[发明专利]取代苯并[de]异喹啉－1,3－二酮类化合物

说明书

本申请是专利申请序列号09/199409的部分继续，该原专利申请在此全文引入作为参考。

本发明涉及式I的取代苯并[de]异喹啉-1，3-二酮类化合物：其中：R是H、A或CH₂-Ph；R¹是-Het、-N-[(CH₂)_s-OH]₂、-N-[(CH₂)_s-OA]₂、-NA-(CH₂)_s-Ar、

-NA-(CH₂)_m-R⁵、-Y-(CH₂)_m-R⁵、-Y-(CH₂)₂-NHA、

-Y-(CH₂)₂-NH-(CH₂)_S-OH、-Y-(CH₂)₂-NA₂、-Y-(CH₂)_m-OH、-Y-(CH₂)_n-(CHR⁴)-R³、

-Y-(CH₂)_n-R⁴、R⁴、-Y-(CH₂)_n-Het-(CH₂)_o-R⁶、

-Y-(CH₂)_n-Ar’-(CH₂)_o-R⁶、-Het-(CH₂)_n-Ar、-Het-Het、-Y-(CH₂)_s-Ar’-(CH₂)_o-R¹¹、

-Y-[X-O]_t-[X¹-O]_u--X²-R⁵或-Y-(CH₂)_n-NA-(CH₂)_o-R⁵；R²是H、OH、OA、COOH、COOA、CH(Ph)-Ph、Ar、Het¹、R⁵、R⁷或R⁸；R³是CH₃，R⁴是-CH＝CH₂、-Ar、COOA、COOH或R⁵是NH₂、NHA、NA₂、NHAr、-NH-(CH₂)_n-OH或-NH-(CH₂)_n-OAR⁶是H或R⁵，R⁷是-Ar’-(CH₂)_n-R⁸或-Ar’-(CH₂)_n-R⁵，R⁸是CONH₂、CONHA、CONA₂、CONH-(CH₂)_o-Ar、CONH-(CH₂)_o-Het、

CONH-(CH₂)_o-R⁵、CONH-(CH₂)_o-CH(Ar¹)-Ar²、CONH-(CH₂)_o-CH(A)-Ph、

CONH-(CH₂)_o-Ar’-NH-CO-Ar、CONH-Ar’-Het或CHA-CONH₂，