[发明专利]基于特异性外周血DNA甲基化位点的人类健康长寿标志物及应用

权利要求书

1.一种基于特异性外周血DNA甲基化位点的人类健康长寿标志物，其特征在于，所述基于特异性外周血DNA甲基化位点为：chr8:50875827，chr8:116677057，chr15:27700163，chr5:30874451，chr5:30874557，chr14:81893050，chr12:74680969，chr1:162818438，chr11:64428940，chr14:81893183，chr3:106982651，chr4:66603635，chr5:33032974，chr8:42749176，chr11:88289243，chr2:30921600，chr12:72664814，chr1:237843796，chr8:116679189，chr9:113207522，chr5:30874442，chr5:76464254，chr8:140441026，chr13:112068869，chr10:33562654，chr8:130694077，chr3:27121417，chr8:139672297，chr3:72202330，chr3:139589624，chr13:87562895，chr12:43746229，chr6:132286889，chr3:1944287，chr7:158260216，chr3:54092416，chr20:54718721，chr5:30874614，chr10:126843788，chr10:10275790，chr15:27699921，chr20:59140762，chr8:70065664，chr3:54092415，chr14:81893218，chr4:172973750，chr5:149995562，chr2:209492906，chr2:82316566，chr3:24283854，chr4:66603446，chr4:172968469，chr4:66603636，chr2:108663577，chr9:85170407，chr2:79007263，chr3:24283899，chr20:19830101，chr18:9335658，chr1:243088019，chr4:172968523，chr15:57205814，chr17:56469038，chr4:130182533，chr16:79642996，chr22:26717474，chr15:88774139，chr4:184797994，chr21:41310315，chr8:75667922，chr3:149094893，chr11:24151395，chr3:149095007，chr2:223921132，chr7:151740319，chr4:172976050，chr5:27825819，chr3:149095284，chr7:7369258，chr8:80268282，chr14:64746787，chr4:172973617，chr3:149094817，chr14:81893209，chr3:149095305，chr3:149095202，chr2:176383009，chr3:149095267，chr7:151740384。

2.权利要求1所述的基于特异性外周血DNA甲基化位点的人类健康长寿标志物在制备人类健康长寿预测产品中的应用，其特征在于，所述预测产品包含一种或多种特异性外周血DNA甲基化位点的试剂，所述试剂通过受试者DNA甲基化位点的甲基化水平，预测评估受试者是否能够实现健康长寿。

3.根据权利要求2所述的应用，其特征在于，所述标志物chr1:154390784的甲基化水平在健康长寿人群中显著增加。