[发明专利]一种手性双噁唑啉金属配合物的用途

说明书

一种手性铂配合物(I)的用途,其用作抗癌试剂在A5499(肺癌)、KB(鼻咽癌)、KB‑VIn(抗耐药性鼻咽癌)、MDA‑MB‑231(人乳腺癌细胞)及MCF‑7(乳腺癌细胞)试验中均显示出较好的的抑制活性，其化学式如下：一种手性锌配合物(I)的用途,其用作抗癌试剂在A549(肺癌)、KB(鼻咽癌)和KB‑VIn(抗耐药性鼻咽癌)、人乳腺癌细胞MDA‑MB‑231及乳腺癌细胞MCF‑7试验中均显示出较好的抑制活性，其化学式如下：

一、技术领域

本发明涉及一种金属噁唑啉有机配位化合物(配合物)的用途，特别涉及含铂及锌双噁唑啉配合物的用途，确切地说是一种含铂及锌双噁唑啉金属配合物在医药领域中的用途。

二、背景技术

金属铂及锌双噁唑啉配合物因其在抗癌和分子磁体、荧光材料等方面的潜在应用价值已引起人们的广泛关注。其合成方法近年来有许多文献报道。【1-7】

1.A Comparative Antimicrobial Study In Between a Quinoline Drug andIts Complexes:Spectral,Kinetic,and Molecular Modeling Investigations,Al-Hazmi,Gamil A.A.；Saad,Fawaz A.Synthesis and Reactivity in Inorganic,Metal-Organic,and Nano-Metal Chemistry(2015),45(11),1743-1757.

2.One-pot synthesis of dual-emitting BSA-Pt-Au bimetallicnanoclusters for fluorescence ratiometric detection of mercury ions andcysteine,Ding,Shou-Nian；Guo,Yun-Xia From Analytical Methods(2015),7(14),5787-5793.

3.Five coordinate platinum(II)in[Pt(bpy)(cod)(Me)][SbF6]:a structuraland spectroscopic study,Klein,Axel；Neugebauer,Michael；Krest,Alexander；Luening,Anna；Garbe,Simon；Arefyeva,Natalia；Schloerer,Nils,Inorganics(2015),3(2),118-138.

4.Synthesis and Reactivity of Platinum(II)cis-Dialkyl,cis-AlkylChloro,and cis-Alkyl Hydrido Bis-N-heterocyclic Carbene Chelate Complexes,Brendel,Matthias；Engelke,Rene；Desai,Vidya G.；Rominger,Frank；Hofmann,Peter,Organometallics(2015),34(12),2870-2878.

5.The Challenge of Deciphering Linkage Isomers in Mixtures ofOligomeric Complexes Derived from 9-Methyladenine and trans-(NH3)2PtII Units,Ibanez,Susana；Mihaly,Bela；Sanz Miguel,Pablo J.；Steinborn,Dirk；Pretzer,Irene；Hiller,Wolf；Lippert,Bernhard Chemistry-A European Journal(2015),21(15),5794-5806.