[发明专利]一种合成α‑烷基芳乙酰胺的方法

说明书

技术领域

本发明属有机合成化学技术领域，具体涉及一种合成α-烷基芳乙酰胺的方法。

背景技术

α-烷基芳乙酰胺是一类独特的结构单元,它广泛地出现在天然产物和药物活性分子中(a)A.M.Aronov.M.A.Murcko,J.Med.Chem.2004,47,5616-5619；b)P.Pevarello,M.G.Brasca,P.Orsini,G.Traquandi,A.Longo,M.Nesi,F.Orzi,C.Piutti,P.Sansonna,M.Varasi,A.Cameron,A.Vulpetti,F.Roletto,R.Alzani,M.Ciomei,C.Albanese,W.Pastori,A.Marsiglio,E.Pesenti,F.Fiorentini,J.R.Bischoff,C.Mercurio,J.Med.Chem.2005,48,2944-2956；c)J.B.Thomas,L.Zhang,H.A.Navarro,F.I.Carroll,J.Med.Chem.2006,49,5597-5609；d)N.Mahindroo,M.C.Connelly,C.Punchihewa,H.Kimura,M.P.Smeltzer,S.Wu,N.Fujii,J.Med.Chem.2009,52,4277-4287；d)Y.Cheung,H.Yu,K.Xu,B.Zou,M.Wu,O.B.McManus,M.Li,C.W.Lindsley,C.R.Hopkins,J.Med.Chem.2012,55,6975-6979；e)J.A.Pfefferkorn,A.Guzman-Perez,J.Litchfield,R.Aiello,J.L.Treadway,J.Pettersen,M.L.Minich,K.J.Filipski,C.S.Jones,M.Tu,G.Aspnes,H.Risley,J.Bian,B.D.Stevens,P.Bourassa,T.D’Aquila,L.Baker,N.Barucci,A.S.Robertson,F.Bourbonais,D.R.Derksen,M.MacDougall,O.Cabrera,J.Chen,A.L.Lapworth,J.A.Landro,W.J.Zavadoski,K.Atkinson,N.Haddish-Berhane,B.Tan,L.Yao,R.E.Kosa,M.V.Varma,B.Feng,D.B.Duignan,A.El-Kattan,S.Murdande,S.Liu,M.Ammirati,J.Knafels,P.DaSilva-Jardine,L.Sweet,S.Liras,T.P.Rolph,J.Med.Chem.2012,55,1318-1333；f)R.Sarabu,F.T.Bizzarro,W.L.Corbett,M.T.Dvorozniak,W.Geng,J.F.Grippo,N.Haynes,S.Hutchings,L.Garofalo,K.R.Guertin,D.W.Hilliard,M.Kabat,R.F.Kester,W.Ka,Z.Liang,P.E.Mahaney,L.Marcus,F.M.Matschinsky,D.Moore,J.Racha,R.Radinov,Y.Ren,L.Qi,M.Pignatello,C.L.Spence,T.Steele,J.Tengi,J.Med.Chem.2012,55,7021-7036)

这类化合物也是构建生物活性分子的关键性中间体.(a)P.L.Ornstein,D.M.Zimmerman,M.B.Arnold,T.J.Bleisch,B.Cantrell,R.Simon,H.Zarrinmayeh,S.R.Baker,M.Gates,J.P.Tizzano,D.Bleakman,J.Med.Chem.2000,43,4354-4358；b)N.Haynes,W.L.Corbett,F.T.Bizzarro,K.R.Guertin,D.W.Hilliard,G.W.Holland,R.F.Kester,P.E. Mahaney,L.Qi,C.L.Spence,J.Tengi,M.T.Dvorozniak,A.Railkar,F.M.Matschinsky,J.F.Grippo,J.Grimsby,R.Sarabu,J.Med.Chem.2010,53,3618-3625)