[发明专利]TAT-LBD-PEP融合蛋白及其在治疗中枢神经系统损伤疾病中的应用

权利要求书

1.一种TAT-LBD-PEP融合蛋白，其特征在于：该融合蛋白的cDNA序列和蛋白序列如下：

cDNA序列：

ATGCGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGCATGACTGGTGGACAGCAAATGGGTCGGGATCTGTACGACGATGACGATAAGGATCGATGGGGATCCAAGCTTGGCTACGGCCGCAAGAAACGCCGCCAGCGCCGCCGCGGTGGATCCACCATGGCCCTGCCGGGCGCATCGGGCACCTGTCCGGAACGCGCACTGGAACGTCGTGAAGAAGAAGCAAATGTTGTCCTGACGGGTACGGTTGAAGAAATTCTGAACGTTGATCCGGTCCAGCATACCTATAGCTGCAAAGTCCGTGTGTGGCGCTACCTGAAAGGCAAGGATCTGGTGGCACGTGAAAGTCTGCTGGACGGCGGTAATAAGGTGGTTATTTCCGGCTTTGGTGATCCGCTGATCTGTGACAACCAAGTCAGTACCGGTGATACGCGCATCTTTTTCGTTAATCCGGCACCGCCGTATCTGTGGCCGGCACATAAAAACGAACTGATGCTGAATAGCTCTCTGATGCGTATTACGCTGCGCAACCTGGAAGAAGTGGAATTTTGCGTTGAAGATAAACCGGGCGGTCTGACGGGTAGCCTGCCGAAACCGATTCTGCGTGTTCAACCGGATAGCGTTGTGAGCCGCCGCACCAAAGTGACCTTCCTGTGTGAAGAAACCATTGGCGCCAACGAATATCGTCTGTACAAAGATGGTAAACTGTATAAAACCGTGACGAAAAACAAACAGAAACCGGAAAATAAAGCTGAATTTAGCTTCTCTAACGTTGATCTGAGCAATGCGGGCCAGTATCGCTGCAGTTACTCCACCCAATATAAAAGCTCTGGCTACTCGGACCTGCTGGAACTGGTGGTTACCGGTCATTATTGGACGCCGAGCCTGCTGGCACAGGCATCACCGGTCGTGACCTCGGGCGGTTATGTTACGCTGCAATGTGAAAGCTGGCATAACGATCACAAATTTATTCTGACCGTCGAAGGCCCGCAGAAACTGAGCTGGACCCAGGACTCTCAATATAATTACAGTACGCGTAAATACCACGCACTGTTCAGCGTCGGTCCGGTGACCCCGAACCAGCGTTGGATCTGCCGCTGTTATTCCTACGATCGTAATCGCCCGTATGTGTGGTCACCGCCGTCAGAATCGGTTGAACTGCTGGTCAGCGGCAACCTGCAGAAACCGACCATTAAAGCAGAACCGGGTTCAGTCATCACCTCGAAACGCGCTATGACGATTTGGTGCCAGGGTAACCTGGACGCGGAAGTGTATTTTCTGCATAACGAAAAATCCCAGAAAACCCAATCAACCCAGACGCTGCAAGAACCGGGCAACAAGGGTAAATTTTTCATCCCGTCTGTTACCCTGCAGCACGCCGGCCAATACCGTTGCTATTGTTACGGCAGTGCAGGTTGGAGCCAGCCGTCTGATACCCTGGAACTGGTTGTCACGGGTATCTATGAATATTACGAACCGCGTCTGAGCGTGCTGCCGTCTCCGGTGGTTACCGCGGGCGGTAACATGACGCTGCATTGTGCCTCCGATTTTCCGTATGACAAATTCATCCTGACCAAAGAAGATAAAAAATTCGGCAATTCACTGGACACGGAACATATCAGTTCCTCAGGCCAGTACCGTGCCCTGTTTATTATCGGTCCGACCACGCCGACCCACACGGGTGCATTCCGCTGCTATGGTTATTACAAAAACGCACCGCAGCTGTGGAGTGTTCCGTCCGCTCTGCAGCAAATTCTGATCTCAGGTCTGTCGAAAAAACCGTCTCTGCTGACCCATCAGGGCCACATCCTGGACCCGGGTATGACCCTGACGCTGCAATGTTTCAGTGATATCAACTACGACCGTTTCGCACTGCATAAAGTGGGCGGTGCTGATATCATGCAGCACTCGAGCCAGCAAACCGACACGGGCTTTTCTGTCGCCAACTTCACCCTGGGTTATGTGTCTAGTTCCACGGGCGGTCAATATCGTTGCTACGGTGCACATAATCTGTCATCGGAATGGAGCGCCAGCTCTGAACCGCTGGATATTCTGATCACCGGTCAGCTGCCGCTGACGCCGAGCCTGTCTGTCCAACCGAATCATACCGTGCACTCGGGTGAAACGGTTAGCCTGCTGTGTTGGAGCATGGATTCTGTTGACACCTTTATTCTGAGTAAAGAAGGCTCCGCTCAGCAACCGCTGCGTCTGAAAAGTAAATCCCATGATCAGCAAAGCCAGGCGGAATTTTCAATGTCGGCCGTGACCAGTCACCTGTCCGGCACGTATCGCTGCTACGGTGCGCAAGACAGTTCCTTCTATCTGCTGTCATCGGCATCTGCTCCGGTGGAACTGACCGTTAGTGGTCCGATTGAAACGAGCACGCCGCCGCCGACGATGTCCATGCCGCTGGGTGGTCTGCATATGTAT；

蛋白质序列：

MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSKLGYGRKKRRQRRRGGSLPGASGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNS SLMRITLRNLEEVEFCVEDKPGGGGSGSLPKPILRVQPD SVVSRRTKVTFLCEETIGANEYRLYKDGKLYKTVTKNKQKPENKAEFSFSNVDLSNAGQYRCSYSTQYKSSGYSDLLELVVTGHYWTPSLLAQASPVVTSGGYVTLQCESWHNDHKFILTVEGPQKLSWTQDSQYNYSTRKYHALFSVGPVTPNQRWICRCYSYDRNRPYVWSPPSESVELLVSGNLQKPTIKAEPGSVITSKRAMTIWCQGNLDAEVYFLHNEKSQKTQSTQTLQEPGNKGKFFIPSVTLQHAGQYRCYCYGSAGWSQPSDTLELVVTGIYEYYEPRLSVLPSPVVTAGGNMTLHCASDFPYDKFILTKEDKKFGNSLDTEHISSSGQYRALFIIGPTTPTHTGAFRCYGYYKNAPQLWSVPSALQQILISGLSKKPSLLTHQGHILDPGMTLTLQCFSDINYDRFALHKVGGADIMQHSSQQTDTGFSVANFTLGYVSSSTGGQYRCYGAHNLSSEWSASSEPLDILITGQLPLTPSLSVQPNHTVHSGETVSLLCWSMDSVDTFILSKEGSAQQPLRLKSKSHDQQSQAEFSMSAVTSHLSGTYRCYGAQDSSFYLLSSASAPVELTVSGPIETSTPPPTMSMPLGGLHMYLK。