[发明专利]一个锌指蛋白家族的人类新基因ZNF329无效
| 申请号： | 01128683.0 | 申请日： | 2001-10-17 |
| 公开（公告）号： | CN1341717A | 公开（公告）日： | 2002-03-27 |
| 发明（设计）人： | 吴秀山;朱传炳;戴琦;袁婺洲;李永清;王跃群;罗开梅;曾伟奇 | 申请（专利权）人： | 湖南师范大学 |
| 主分类号： | C12N15/11 | 分类号： | C12N15/11;C12N15/12;C07H21/04;C07K14/435;C07K14/47 |
| 代理公司： | 湖南兆弘专利事务所 | 代理人： | 赵洪 |
| 地址： | 410081 湖南省长沙市河西岳*** | 国省代码： | 湖南;43 |
| 权利要求书： | 暂无信息 | 说明书： | 暂无信息 |
| 摘要： | 本发明涉及锌指蛋白家族基因。本发明的一个锌指蛋白家族的人类新基因ZNF329,它的cDNA全长2918bp,编码542个氨基酸组成的蛋白质;该基因位于第19染色体的BAC2623H2上,共有5个外显子,跨越基因组24.6kb,BAC定位于19q13.4区域;经Northern杂交,表明该基因在胚胎发育的不同阶段的表达存在差异。 | ||
| 搜索关键词： | 一个 蛋白 家族 人类 基因 znf329 | ||
【主权项】：
1、一个锌指蛋白家族的人类新基因ZNF329，其特征在于该人类新基因ZNF329的cDNA核苷酸序列与氨基酸序列如下：＞znf329的cDNA序列exon1TAA34AATGCCTGCGCGTCCGCCCCGAGGCAAGTCCACGCCAGGGTAATG4849AATAACCCGGTACCCGCGGCCGCCCCAGCGTTGGGCGGGGGAAGC9394TCGGGGACTCCGCGCACGCGCACATCCTTGTCCCGGCAGCCGCGC138exon2139AAGCGCAATCGCCCGGAACATGGCTGCCGCCGGCCGCCAACC/GAT183184GGCTGGAGCCGTGTGGATGGGCATAAATGGCTAATGTCCAGCAAC228229CATCGATGTCAAGTATCCACACACCTGGCCTGAATGGATCCCTCT273exon3274GCCTTTCAGA/GAGTTTGGGATATGAGATTGAAAATGACGACTCGG318319AATTTTCCTGAGAGAGAAGTACCCTGTGATGTAGAAGTGGAAAGA363364TTCACAAGGGAAGTTCCCTGCTTGTCCAGTTTAGGTGATGGTTGG408409GACTGTGAGAACCAGGAGGGACACTTGAGGCAATCAGCTTTAACT453454CTGGAGAAACCAGGGACTCAGGAAGCAATTTGTGAATATCCTGGT498499TTTGGGGAGCATTTGATTGCAAGCTCAGACCTTCCACCGTCTCAG543544AGAGTTCTGGCAACAAATGGTTTCCATGCACCTGACTCAAATGTT588589AGTGGTCTGGATTGTGACCCCGCCTTACCCAGCTATCCTAAAAGT633634TATGCAGATAAGAGAACTGGTGACAGTGATGCCTGTGGAAAAGGC678679TTCAACCATTCCATGGAAGTTATTCATGGAAGAAATCCAGTGAGA723exon4724GAGAAGCCCT/ATCATTTTACCTCTCTTGGTCATCAGAAAATAATG768769AAAAGAGGCAAGAAATCGTATGAAGGTAAGAATTTTGAGAACATC813814TTTACTCTGAGCTCATCGCTTAATGAAAACCAGAGAAATCTCCCT858859GGAGAGAAACAATATAGATGTACTGAATGTGGCAAATGCTTCAAA903904CGGAACTCTTCTCTTGTTTTGCATCACCGAACTCACACCGGAGAG948949AAGCCTTATACTTGTAATGAGTGTGGAAAGTCCTTCTCCAAGAAC993(后续)994TACAACCTGATTGTGCATCAAAGAATCCACACAGGAGAGAAGCCC10381039TATGAATGCAGTAAATGTGGGAAAGCTTTCAGTGATGGCTCAGCT10831084CTGACACAGCACCAGAGAATTCACACAGGCGAGAAACCTTATGAA11281129TGCCTAGAGTGTGGAAAAACCTTCAACCGAAATTCATCCTTAATT11731174TTGCACCAAAGAACTCATACAGGGGAAAAACCATATAGATGTAAC12181219GAATGTGGGAAACCCTTCACTGACATCTCCCACCTTACAGTGCAT12631264CTCAGAATCCACACCGGTGAGAAGCCCTATGAGTGTAGCAAATGT13081309GGAAAGGCTTTCCGGGACGGCTCGTACCTCACCCAGCATGAGAGG13531354ACTCACACTGGAGAAAAGCCCTTTGAGTGTGCAGAGTGCGGGAAA13981399TCCTTCAACAGAAACTCTCACCTCATTGTGCATCAAAAGATCCAT14431444TCTGGGGAGAAACCCTATGAATGTAAAGAATGTGGCAAGACTTTC14881489ATCGAGAGTGCGTACCTCATCAGGCATCAGAGGATTCATACTGGC15331534GAGAAGCCCTATGGCTGCAACCAGTGTCAGAAACTTTTCAGGAAT15781579ATCGCTGGCCTCATTAGGCACCAGAGGACTCATACTGGTGAGAAG16231624CCCTATGAGTGTAATCAGTGTGGCAAAGCCTTCAGGGACAGCTCC16681669TGTCTGACCAAGCACCAGAGAATTCACACTAAGGAGACCCCATAT17131714CAGTGTCCAGAATGTGGGAAGTCCTTCAAGCAGAACTCTCACCTG17581759GCAGTACATCAGAGACTCCATAGCAGGGAGGGTCCCAGCCGGTGT18031804CCTCAGTGTGGAAAAATGTTCCAAAAGAGCTCATCCCTTGTTCGA18481849CATCAAAGAGCACACCTGGGAGAGCAACCCATGGAAACATAATGG18931894TTGGGGGCCACATGAGTCTTCCAGTTCACTCTCACTCCTGTGTTT19381939AGGAGGCGTGTCTTAGATCTGACTCCTCTCTGGTCAGTAGAAAAG19831984AATCCTTTAAGCTATCCAGTGAATTGATGAATGTGAGACATTGCT20282029GAGCCACACTGTTAAGTCTGCTCATTGGGGAACTCCAGAGACAAC20732074TTAGGATGAGGGCAGAAAAGTCTTTGGGGATGATTCAGTCTGTAC21182119CAGACATGACAACACACACACTGGAATGAAATGTGCAAACATGGG21632164GGTGACACCACAGAGAGAACCTGTGAATGCATTCAGAACATGATT22082209GGAATGAAGAGCCCTGTAGTAGGGAGTTTCCACCTTGTACGTAAG22532254CAAACACTGAATCAACTTTTTTTTTTTTTTCGGACAGAGTCTCAC2298(后续)2299TGTGCAGTGGCATGATCTCCACTCACAGCAACCTCTGCCTCCCAG2343exon52344GTTCAAGCAGTTCTCCTGCC/TCAGCCTGGCCAGCATGGTGAAACC23882389CCATCTCTACCAAAAATACAGGAAATTATCTGGGCATAGTAGTGT24332434GTGCCTGTAATCCCAGCTACTTGGGAAGCTGAGGCAGGAGAATTG24782479CTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTAAGATCGCACCA25232524CTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCATTTCAAAAAA25682569AAAGACTGAAACAAGCTTGTGCTAAGATGGAAAGGGCTGCTTCTA26132614ACAGATGTGGTTTGTTGCTTTAGTTGTTGAAGCAAAAATACTGAG26582659TTGTTATGTTTATGTTATCACCCCACCACTACCTCCATGGTTGTT27032704CATTTAGGATGCTTCTAATTCAGCCACTGTGAACCATTATAAAGG27482749TTTTATTGCCATGTTGAAAATGTTTATAATATGGCAAAAAGGGGC27932794ATCAAATAGAAGATTTACTATTATTCCAGCCATGTAAAAATATGT28382839GCACATATGGATGTATGTTGAAAGTGGATGATGGAGAAATAAAAT28832884GTGGTTTTCTTTGGGGACTGGAAAAAAAAAAAAAAA2919＞znf329的编码蛋白1MetAspProSer45AlaPheGlnArgValTrpAspMetArgLeuLysMetThrThrArg1920AsnPheProGluArgGluValProCysAspValGluValGluArg3435PheThrArgGluValProCysLeuSerSerLeuGlyAspGlyTrp4950AspCysGluAsnGlnGluGlyHisLeuArgGlnSerAlaLeuThr6465LeuGluLysProGlyThrGlnGluAlaIleCysGluTyrProGly7980PheGlyGluHisLeuIleAlaSerSerAspLeuProProSerGln9495ArgValLeuAlaThrAsnGlyPheHisAlaProAspSerAsnVal109110SerGlyLeuAspCysAspProAlaLeuProSerTyrProLysSer124125TyrAlaAspLysArgThrGlyAspSerAspAlaCysGlyLysGly139140PheAsnHisSerMetGluValIleHisGlyArgAsnProValArg154155GluLysProTyrHisPheThrSerLeuGlyHisGlnLysIleMet169(后续)170LysArgGlyLysLysSerTyrGluGlyLysAsnPheGluAsnIle184185PheThrLeuSerSerSerLeuAsnGluAsnGlnArgAsnLeuPro199200GlyGluLysGlnTyrArgCysThrGluCysGlyLysCysPheLys214215ArgAsnSerSerLeuValLeuHisHisArgThrHisThrGlyGlu229230LysProTyrThrCysAsnGluCysGlyLysSerPheSerLysAsn244245TyrAsnLeuIleValHisGlnArgIleHisThrGlyGluLysPro259260TyrGluCysSerLysCysGlyLysAlaPheSerAspGlySerAla274275LeuThrGlnHisGlnArgIleHisThrGlyGluLysProTyrGlu289290CysLeuGluCysGlyLysThrPheAsnArgAsnSerSerLeuIle304305LeuHisGlnArgThrHisThrGlyGluLysProTyrArgCysAsn319320GluCysGlyLysProPheThrAspIleSerHisLeuThrValHis334335LeuArgIleHisThrGlyGluLysProTyrGluCysSerLysCys349350GlyLysAlaPheArgAspGlySerTyrLeuThrGlnHisGluArg364365ThrHisThrGlyGluLysProPheGluCysAlaGluCysGlyLys379380SerPheAsnArgAsnSerHisLeuIleValHisGlnLysIleHis394395SerGlyGluLysProTyrGluCysLysGluCysGlyLysThrPhe409410IleGluSerAlaTyrLeuIleArgHisGlnArgIleHisThrGly424425GluLysProTyrGlyCysAsnGlnCysGlnLysLeuPheArgAsn439440IleAlaGlyLeuIleArgHisGlnArgThrHisThrGlyGluLys454455ProTyrGluCysAsnGlnCysGlyLysAlaPheArgAspSerSer469470CysLeuThrLysHisGlnArgIleHisThrLysGluThrProTyr484485GlnCysProGluCysGlyLysSerPheLysGlnAsnSerHisLeu499500AlaValHisGlnArgLeuHisSerArgGluGlyProSerArgCys514515ProGlnCysGlyLysMetPheGlnLysSerSerSerLeuValArg529530HisGlnArgAlaHisLeuGlyGluGlnProMetGluThr
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